Sanofi Group Head of Pre-Clinical Safety Operations in Framingham, Massachusetts
Head of Pre-Clinical Safety Operations
Sanofi, a global healthcare leader, discovers, develops and distributes therapeutic solutions focused on patients’ needs. Sanofi has core strengths in diabetes solutions, human vaccines, innovative drugs, consumer healthcare, emerging markets, animal health and Genzyme.
At Sanofi US, we are committed to the growth of our people, connected in purpose by career, life and health.
Headquartered in Bridgewater, NJ, Sanofi US is part of a leading global healthcare company dedicated to discovering, developing and distributing therapeutic solutions focused on patients’ needs.
Sanofi has core strengths in diabetes solutions, human vaccines, innovative drugs, consumer healthcare, emerging markets, animal health and Genzyme.
Sanofi US employs approximately 17,000 people across the country all dedicated to protecting health, enhancing life and responding to the hopes and potential healthcare needs of seven billion people around the world.
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Head Preclinical Safety (PS) Operations/Investigative Toxicology Boston R&D Hub
In pharmaceutical industry, one of the major challenges in the discovery of innovative medicines is to ensure they are safe enough to serve patients – that is our mission. Drug safety is assessed throughout the R&D value chain, but it is during early drug discovery when we can actively design safety attributes into future candidate drug. We are supporting Drug Hunting partners in identification and optimization of new biologics and small molecule series applying cutting edge technologies pushing to the boundaries of predictive safety science with our mission in mind.
For our preclinical safety team in Boston, USA, (total 6 staff) we are looking for a Leader of the team with focus on Investigative Toxicology. Activities include, but are not limited to:
Leading the investigative toxicology team in Boston R&D Hub. Member of the global PS Leadership Team.
Collaborate transversally on a global level (France, Germany) with investigative toxicology teams and global expert/advisory groups on early safety and investigative toxicology.
Strongly Interact locally and globally with the discovery and development toxicology project heads
Develop together innovative solutions and research proposals to pursue cutting edge science and technologies in order to optimize and influence translational safety assessment of novel drug targets.
Serve as internal expert for local discovery and global development projects and design project-specific strategies to predict, assess and mitigate target- and modality-related safety risks and execute through internal and external experimental capabilities.
Provide project team members to local discovery project teams for the progression of both biologics and small molecules for regulatory submissions regulatory submission.
Engage with experts across the organization to ensure that teams are able to make the right decisions regarding the translational safety risks associated with the project.
Continuously interact with multiple R&D functions (Pharmacology, DMPK, Translational Medicine &Early Development, Project Leaders & Managers etc.)
Hold PS Department activities (staff meeting, scientific forums, etc.), and special projects
Participate in special projects or inter-industry working groups, as needed. Provide scientific input on design and analysis of research activities
Ensure high scientific standards / adhering to requested timelines in all aspects of the position
Supervision / Development of laboratory staff
Job requirements (education and experience) include:
PhD or DVM and post-doctoral experience in toxicology, biochemistry, pharmacology, cell biology or systems biology. In addition, the candidate should have knowledge in biochemistry, toxicology, pharmacology, biology, physiology, and pathology.
Solid understanding of the drug discovery and development process based on more than 5-8 years of experience in pharmaceutical industry as project Team representative and ideally study director in the eSafety and investigative toxicology space.
Hands-on experience with in vitro toxicology, pharmacology and/or molecular biology experimentation to investigate molecular mechanisms of drug action is critical.
Experience with the design and execution of in vitro/in vivo experiments to determine the effects of therapeutics on biological systems, with line of sight to human safety risk understanding.
Knowledgeable about regulatory nonclinical testing requirements for pharmaceutical development of biologics and small molecules
Strong leadership competencies and experience
Highly motivated, creative, innovative, reliable scientist, with a flexible, collaborative, team-oriented mindset, who solves problems in a goal-focused fashion.
A social personality that contributes to an open, positive, collaborative working climate.
Strong communication, presentation and influencing skills across levels/disciplines.
Willingness to collaborate globally and to establish a fully aligned investigative toxicology environment across all engaged R&D Hubs
DABT certification and experience as GLP Study Director is preferred, but not required.
Job: Laboratory/Process/Device Development
Primary Location: United States-Massachusetts-Framingham
Job Posting: Feb 10, 2017, 9:46:03 PM
Job Type: Regular
Employee Status: Regular