Sanofi Group Scientist, in vitro antibody discovery in Framingham, Massachusetts
Scientist, in vitro antibody discovery
Sanofi Genzyme focuses on developing specialty treatments for debilitating diseases that are often difficult to diagnose and treat, providing hope to patients and their families.
Genzyme Corporation (a Sanofi company) and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
Job Responsibilities/Department Description:
A motivated candidate is sought to join the in vitro antibody discovery team to discover and characterize potential therapeutic antibodies for the Sanofi biologics pipeline. The candidate will be required to manipulate Fab and scFv antibody phage libraries in order to isolate antibodies against a number of targets for different therapeutic disease areas. The successful candidate will be responsible for the design and execution of selection and screening strategies to isolate high affinity antibodies that meet criteria such as species cross-reactivity and biological function. Optimization of antibodies will be performed through the design, generation and mining of affinity maturation libraries. The core display platform will be phage display, with the potential for mammalian display in the future. Laboratory techniques will include generation and manipulation of antibody libraries; selection strategies on bead/solid surface/cell expressed antigen formats; high throughput binding assays; antibody fragment expression and analysis; molecular biology; and sequence analysis. The role will require the use of state-of-the-art automation and data management software for sample tracking and thorough data analysis.
The candidate is expected to present data to scientists at team, group and wider meeting forums.
Sufficient expertise is required to work in an independent fashion in the design of experiments, analysis, reporting and next step planning.
Ph.D. degree in immunology, biochemistry, or other biological science with 0-2 years of experience in at least one in vitro display technology (phage, mammalian, yeast) is required. The candidate will be experienced in molecular biology technologies, laboratory automation platforms (e.g. liquid handling), and antibody binding techniques (ELISA, FACS, SPR, western blot).
The successful candidate should also have demonstrated excellence with verbal and written communication skills.
Job: Laboratory/Process/Device Development
Primary Location: United States-Massachusetts-Framingham
Job Posting: Aug 30, 2016, 10:30:02 AM
Job Type: Regular
Employee Status: Regular