AbbVie Sr. Scientist, Functional Genomics of Immuno-Oncology in Lake County, Illinois
AbbVie (NYSE:ABBV) is a global, research-based biopharmaceutical company formed in 2013 following separation from Abbott. AbbVie combines the focus and passion of a leading-edge biotech with the expertise and capabilities of a long-established pharmaceutical leader to develop and market advanced therapies that address some of the world’s most complex and serious diseases. AbbVie is committed to the discovery and development of new medicines that make a remarkable impact on the lives of patients. The AbbVie Discovery organization is seeking to hire a genomic technology expert within the Target Enabling Science and Technology Department’s Genomics Research Center (GRC).
Functional Genomics within the AbbVie GRC is seeking a highly motivated PhD scientist who can take advantage of state-of-the-art functional genomic technologies and lead multidisciplinary discovery and translational projects to help advance AbbVie’s R&D pipeline in immuno-oncology. The successful hire will investigate molecular and cellular mechanisms of adaptive and innate immunity against tumors, using various in vitro and in vivo models empowered by functional genomics approaches based on CRISPR and next-generation sequencing (NGS). The Scientist will further utilize the knowledge derived from such investigations to identify and validate novel therapeutic targets, understand mechanisms of drug responders and non-responders, identify combination targets for existing therapeutics, and determine functional implications of human genetic variants. Areas of investigation will include, but not be limited to, novel immune-suppressive agents in tumor microenvironment, suppression of tumor antigen presentation, immune cell trafficking and tumor infiltration, and synergistic intervention of known immune checkpoint pathways.
Responsibilities: * Develop novel, testable hypotheses through intellectual processes involving literature review, exchange of scientific ideas by participation in internal and external scientific communities, and bioinformatic data mining. * Design and perform laboratory experiments to test these hypotheses, interpret results and troubleshoot experiments. * Develop CRISPR functional genomic screening approaches based on in vitro and in vivo immune models to identify and validate key regulators of anti-tumor immunity, and to elucidate molecular and cellular mechanisms behind therapeutic intervention of tumor progression. * Collaborate closely with drug discovery and translational teams in immuno-oncology therapeutic area and functional area experts in NGS, bioinformatics, in vivo pharmacology, and high throughput screening. * Lead technology innovations to drive future discovery efforts by taking advantage of available resources in human genetics, genomics, proteomics, automation infrastructure, bioinformatics, and other advanced technologies, and by exercising creativity, innovative thinking, and calculated risk-taking behaviors. * Learn new skills in functional genomics, lentiviral delivery, flow cytometry, in vivo models, etc. as needed, and productively utilize them in his/her projects. * Manage cross-functional research projects across therapeutic areas and sites to drive performance and deliver high-quality results in a timely manner. * Present research data to project teams, larger organizations, and senior management, and publish them in peer-reviewed journals. * Train and mentor junior colleagues and peer scientists in immuno-oncology, flow cytometry, and/or in vivo biology in matrix project environment.
Position will be hired based on Education and Experience*
Basic: * Bachelors Degree, Masters degree, or PhD in immunology, cancer immunology, immuno-oncology, or immuno-genomics with 10 (BS), 8 (MS) or 0 (Ph.D) years of relevant research or postdoctoral experience in academia or industry. * Expertise in cellular immunological analyses including flow cytometry and sorting of human and mouse immune cells such as T, B, NK, DC, monocytes, and macrophages. * Proficiency in diverse cell and molecular techniques including primary or stem cell isolation and culture, transfection, lentiviral transduction, western blotting, qRT-PCR, etc. * Basic understanding of various genomic technologies such as CRISPR, RNAi, NGS, and RNA Seq * Direct or indirect experience in mouse models of human cancer or autoimmune disease * Evidence of independent research capability including hypothesis development, experimental design and testing, data interpretation, problem solving, and project management * Minimum of one first-author research paper published in well-respected scientific journals * Ability to learn new skills and use them productively in a highly collaborative, fast-paced matrix research environment * Strong desire to work in biopharmaceutical R&D settings to translate basic discovery into medicine Preferred: * PhD in immunology, cancer immunology, immuno-oncology, or immuno-genomics Key Leadership Competencies: Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance. Learns fast, grasps the "essence" and can change course quickly where indicated. Raises the bar and is never satisfied with the status quo. Creates a learning environment, open to suggestions and experimentation for improvement. Embraces the ideas of others, nurtures innovation and manages innovation to reality.
Job Classification: Experienced
Job: RESEARCH AND DEVELOPMENT
Primary Location: USA-Illinois-Lake County
Organization: Research & Development
Travel: Yes, 5 % of the Time
Req ID: 1606421
Equal Opportunity Employer Minorities/Women/Veterans/Disabled